7 The Incredible Hulk Annual Vol 1 6 (1977) Marvel Comics
WRITER: Herb Trimpe
ARTIST: Frank Giacoia
This is the first appearance of Ayesha, aka Paragon, aka HER. The rumor is out she is the main villain in GotG 2 next year. Marvel Two-In-One #61* is also gaining steam as it is the first appearance of Paragon/Ayesha as HER. Confused yet? I am, but these books are hot right now.
*Thanks to nhhs96 for the catch!